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Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP-5862, in patients with B-cell malignancies and in healthy subjects using a population pharmacokinetic approach.
Edlund, Helena; Bellanti, Francesco; Liu, Huan; Vishwanathan, Karthick; Tomkinson, Helen; Ware, Joseph; Sharma, Shringi; Buil-Bruna, Núria.
Afiliação
  • Edlund H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Bellanti F; Certara USA, Inc., Princeton, NJ, USA.
  • Liu H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, MA, USA.
  • Vishwanathan K; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, MA, USA.
  • Tomkinson H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Ware J; Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, CA, USA.
  • Sharma S; Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, CA, USA.
  • Buil-Bruna N; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Br J Clin Pharmacol ; 88(2): 846-852, 2022 02.
Article em En | MEDLINE | ID: mdl-34265100
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / Neoplasias Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / Neoplasias Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia