Biomimetic recombinant of red blood cell membranes for improved photothermal therapy.
J Nanobiotechnology
; 19(1): 213, 2021 Jul 18.
Article
em En
| MEDLINE
| ID: mdl-34275480
ABSTRACT
BACKGROUND:
RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function.RESULTS:
In this study, we reported a green technology of "disassembly-reassembly" to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780.CONCLUSIONS:
The reported "disassembly-reassembly" strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomimética
/
Membrana Eritrocítica
/
Terapia Fototérmica
Limite:
Animals
Idioma:
En
Revista:
J Nanobiotechnology
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China