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Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability.
Dultz, Georg; Srikakulam, Sanjay K; Konetschnik, Michael; Shimakami, Tetsuro; Doncheva, Nadezhda T; Dietz, Julia; Sarrazin, Christoph; Biondi, Ricardo M; Zeuzem, Stefan; Tampé, Robert; Kalinina, Olga V; Welsch, Christoph.
Afiliação
  • Dultz G; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Srikakulam SK; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus, Saarbrücken, Germany; Graduate School of Computer Science, Saarland University, Saarbrücken, Germany; Interdisciplinary Graduate School of Natural Product Research, S
  • Konetschnik M; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Shimakami T; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.
  • Doncheva NT; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
  • Dietz J; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Sarrazin C; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Biondi RM; Molecular Targeting, Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina.
  • Zeuzem S; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Tampé R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Kalinina OV; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus, Saarbrücken, Germany; Medical Faculty, Saarland University, Homburg, Germany; Center for Bioinformatics, Saarland Informatics Campus, Saarbrücken, Germany.
  • Welsch C; Department of Internal Medicine 1, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany. Electronic address: christoph.welsch@kgu.de.
J Biol Chem ; 297(3): 101031, 2021 09.
Article em En | MEDLINE | ID: mdl-34339738
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus / Epistasia Genética Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus / Epistasia Genética Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha