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[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
Liu, Longbin; Johnson, Peter D; Prime, Michael E; Khetarpal, Vinod; Lee, Matthew R; Brown, Christopher J; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Heßmann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E; Mills, Matthew R; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnäs, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A; Dominguez, Celia.
Afiliação
  • Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Johnson PD; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Prime ME; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Brown CJ; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Chen X; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Clark-Frew D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Coe S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Conlon M; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Davis R; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Ensor S; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Esposito S; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30,600, Pomezia, Rome 00071, Italy.
  • Moren AF; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Gai X; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Green S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Greenaway C; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Haber J; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Halldin C; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Hayes S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Herrmann F; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.
  • Heßmann M; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.
  • Hsai MM; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Kotey A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Mangette JE; Albany Molecular Research, Inc., 1001 Main Street, Buffalo, New York 14203, United States.
  • Mills MR; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Monteagudo E; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Nag S; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Nibbio M; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30,600, Pomezia, Rome 00071, Italy.
  • Orsatti L; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30,600, Pomezia, Rome 00071, Italy.
  • Schaertl S; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.
  • Scheich C; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany.
  • Sproston J; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.
  • Stepanov V; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Varnäs K; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Varrone A; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden.
  • Wityak J; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Mrzljak L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Bard JA; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
  • Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.
J Med Chem ; 64(16): 12003-12021, 2021 08 26.
Article em En | MEDLINE | ID: mdl-34351166
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Encéfalo / Compostos Radiofarmacêuticos / Agregados Proteicos / Proteína Huntingtina / Compostos Heterocíclicos com 3 Anéis Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Encéfalo / Compostos Radiofarmacêuticos / Agregados Proteicos / Proteína Huntingtina / Compostos Heterocíclicos com 3 Anéis Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos