Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.
Herz
; 47(3): 251-257, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-34351431
ABSTRACT
INTRODUCTION:
Data regarding the possible role of heparanase (HPA) in the occurrence of left atrial/left atrial appendage (LA/LAA) thrombus in patients with atrial fibrillation (AF) is lacking. The goal of the present study was to assess the association between plasma levels of HPA and LA/LAA thrombus in AF.METHODS:
A total of 687 patients with nonvalvular AF (NVAF) without anticoagulation therapy were included from January 2016 to June 2019. Serum HPA analysis was performed with a commercially available human ELISA kit. Logistic regression models were used to test for association.RESULTS:
Serum HPA levels were significantly higher in patients with LA/LAA thrombus than in those without LA/LAA thrombus (270.8 [193.4⯱ 353.2] pg/mL vs 150.3 [125.2⯱ 208.4] pg/mL; Pâ¯< 0.001). In multivariate analysis, serum HPA remained a significantly independent predictor of LA/LAA thrombus (odds ratio 1.674, 95% confidence interval [CI] 1.339-2.289, Pâ¯< 0.001). In the receiver operating characteristic (ROC) curve analysis, HPA showed a predictive value with an area under the curve (AUC) of 0.757 (95% CI 0.652-0.810, Pâ¯< 0.001). The optimal cutoff level for HPA predicting LA/LAA thrombus was 210.7â¯pg/mL, with a sensitivity of 74.3% and a specificity of 64.8%.CONCLUSION:
An elevated HPA level was associated with the presence of LA/LAA thrombus in patients with AF. HPA might portend the risk for the prothrombotic state in AF patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Trombose
/
Apêndice Atrial
/
Cardiopatias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Herz
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Turquia