Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP.

Harkness, Robert W; Toyama, Yuki; Ripstein, Zev A; Zhao, Huaying; Sever, Alexander I M; Luan, Qing; Brady, Jacob P; Clark, Patricia L; Schuck, Peter; Kay, Lewis E

Harkness, Robert W; Toyama, Yuki; Ripstein, Zev A; Zhao, Huaying; Sever, Alexander I M; Luan, Qing; Brady, Jacob P; Clark, Patricia L; Schuck, Peter; Kay, Lewis E.

Afiliação

Harkness RW; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; r.harkness@utoronto.ca kay@pound.med.utoronto.ca.
Toyama Y; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Ripstein ZA; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Zhao H; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
Sever AIM; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Luan Q; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Brady JP; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Clark PL; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
Schuck P; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Kay LE; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Proc Natl Acad Sci U S A ; 118(32)2021 08 10.

Article em En | MEDLINE | ID: mdl-34362850

Assuntos

Proteínas de Choque Térmico/química; Proteínas de Choque Térmico/metabolismo; Proteínas Periplásmicas/química; Proteínas Periplásmicas/metabolismo; Serina Endopeptidases/química; Serina Endopeptidases/metabolismo; Microscopia Crioeletrônica; Difusão Dinâmica da Luz; Proteínas de Choque Térmico/genética; Chaperonas Moleculares/química; Chaperonas Moleculares/metabolismo; Mutação; Ressonância Magnética Nuclear Biomolecular/métodos; Concentração Osmolar; Proteínas Periplásmicas/genética; Domínios Proteicos; Redobramento de Proteína; Serina Endopeptidases/genética; Temperatura

Palavras-chave

hydrodynamics; methyl-TROSY NMR; protein self-assembly; protein thermodynamics and kinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Serina Endopeptidases / Proteínas Periplásmicas / Proteínas de Choque Térmico Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

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