THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.
Wiad Lek
; 74(7): 1595-1599, 2021.
Article
em En
| MEDLINE
| ID: mdl-34459757
ABSTRACT
OBJECTIVE:
Theaim:
Matrix metalloproteinases (MMP) play an important role in the architecture and remodeling of the lungs. There are 2 gene families of MMP among significantly different genes - MMP-1 and MMP-12, which are closely related to the pathophysiological processes of allergic inflammation, damage and restoration of tissues and the body's defense against pathogens. PATIENTS ANDMETHODS:
Materials andmethods:
70 examined children were divided into 2 groups 37 children who had acute recurrent bronchitis complicated by wheezing syndrome, the comparison group included 33 children with acute bronchitis. The determination of gene polymorphism was carried out using ELISA analysis.RESULTS:
Results:
In the dominant model, carriers of the 2G allele genotypes had 3,45 times lower risk of wheezing syndrome compared with patients with the 1G/1G genotype (OR = 3,45, 95% CI 1,07-11.15, p<0,05). In the dominant model, carriers of G-allele genotypes had a 4,2-fold lower risk of wheezing syndrome compared with patients with the AA genotype (OR = 4,2; 95% CI (CI) = 1,09- 16,09; p <0,05).CONCLUSION:
Conclusions:
Polymorphism rs1799750 in the MMP-1 gene increases the risk of developing the wheezing syndrome among children with acute recurrent bronchitis in 3,5 times. The rs2276109 polymorphism in the MMP-12 gene reduces the risk of wheezing syndrome by 4,2 times among children with acute recurrent bronchitis.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bronquite
/
Metaloproteinase 1 da Matriz
/
Metaloproteinase 12 da Matriz
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
Wiad Lek
Assunto da revista:
MEDICINA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Ucrânia