Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease.
Mol Cell
; 81(19): 3888-3903, 2021 10 07.
Article
em En
| MEDLINE
| ID: mdl-34464593
ABSTRACT
The development and functional potential of metazoan cells is dependent on combinatorial roles of transcriptional enhancers and promoters. Macrophages provide exceptionally powerful model systems for investigation of mechanisms underlying the activation of cell-specific enhancers that drive transitions in cell fate and cell state. Here, we review recent advances that have expanded appreciation of the diversity of macrophage phenotypes in health and disease, emphasizing studies of liver, adipose tissue, and brain macrophages as paradigms for other tissue macrophages and cell types. Studies of normal tissue-resident macrophages and macrophages associated with cirrhosis, obese adipose tissue, and neurodegenerative disease illustrate the major roles of tissue environment in remodeling enhancer landscapes to specify the development and functions of distinct macrophage phenotypes. We discuss the utility of quantitative analysis of environment-dependent changes in enhancer activity states as an approach to discovery of regulatory transcription factors and upstream signaling pathways.
Palavras-chave
ATAC-seq; Alzheimer's disease; Disease associated microglia; Hematopoietic progenitor cells; Hematopoietic stem cells; Kupffer Cell; Lipid associated macrophages; Macrophage; NFkB; Nonalcoholic steatohepatitis; PU.1; Scar associated macrophages; TLR4; Trem2; enhancer; epigenetic; histone acetylation; lipopolysaccharide; microglia; obesity
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Ativação Transcricional
/
Elementos Facilitadores Genéticos
/
Regiões Promotoras Genéticas
/
Microglia
/
Macrófagos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Cell
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos