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Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood-testis barrier and a subtherapeutic effect of cysteamine in testis.
Reda, Ahmed; Veys, Koenraad; Kadam, Prashant; Taranta, Anna; Rega, Laura Rita; Goffredo, Bianca M; Camps, Chelsea; Besouw, Martine; Cyr, Daniel; Albersen, Maarten; Spiessens, Carl; de Wever, Liesbeth; Hamer, Robert; Janssen, Mirian C H; D'Hauwers, Kathleen; Wetzels, Alex; Monnens, Leo; van den Heuvel, Lambertus; Goossens, Ellen; Levtchenko, Elena.
Afiliação
  • Reda A; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  • Veys K; Biology of the Testis (BITE) Laboratory, Department of Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Kadam P; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  • Taranta A; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
  • Rega LR; Biology of the Testis (BITE) Laboratory, Department of Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Goffredo BM; Renal Diseases Research Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Camps C; Renal Diseases Research Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Besouw M; Laboratory of Pediatric Medicine, Laboratory of Metabolic Diseases, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
  • Cyr D; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  • Albersen M; Department of Pediatric Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Spiessens C; Laboratory for Reproductive Toxicology, Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Quebec, Canada.
  • de Wever L; Department of Urology, University Hospitals Leuven, Leuven, Belgium.
  • Hamer R; Fertility Center, Department of Gynaecology, University Hospitals Leuven, Leuven, Belgium.
  • Janssen MCH; Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
  • D'Hauwers K; Department of Radiology, Radboud UMC, Nijmegen, Netherlands.
  • Wetzels A; Department of Internal Medicine, Radboud UMC, Nijmegen, Netherlands.
  • Monnens L; Department of Internal Medicine, Radboud UMC, Nijmegen, Netherlands.
  • van den Heuvel L; Department of Internal Medicine, Radboud UMC, Nijmegen, Netherlands.
  • Goossens E; Department of Internal Medicine, Radboud UMC, Nijmegen, Netherlands.
  • Levtchenko E; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
J Inherit Metab Dis ; 44(6): 1393-1408, 2021 11.
Article em En | MEDLINE | ID: mdl-34494673
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Barreira Hematotesticular / Cisteamina / Cistinose / Azoospermia Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Barreira Hematotesticular / Cisteamina / Cistinose / Azoospermia Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: J Inherit Metab Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica