The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.
Osteoporos Int
; 33(2): 327-338, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34532766
ABSTRACT
PURPOSE:
To determine the pooled effect of exercise on the bone health of people diagnosed with cancer.METHODS:
Four electronic databases were systematically searched. Controlled trials that assessed the effect of exercise on the bone mineral density (BMD) or content (BMC) measured by dual-energy x-ray absorptiometry or peripheral quantitative computed tomography in people who had been diagnosed with cancer were included in the study. Random-effect meta-analyses of effect size (ES) were conducted. Sub-group analyses were performed to explore the influence of intervention duration, prescription and participant characteristics.RESULTS:
Of 66 full-text articles screened, 22 studies, from 21 interventions, were included (primarily breast/prostate cancer, sample range n = 36-498). When all interventions were grouped, a significant pooled ES was observed for exercise on hip (ES = 0.112, 95% CI 0.026 to 0.198; p = 0.011) and lumbar spine BMD (ES = 0.269, 95% CI 0.036 to 0.501; p = 0.024) compared to control. There was also an influence of sex, where females had greater improvements in hip (ES = 0.120, 95% CI 0.017 to 0.223; p = 0.022) and spine BMD (ES = 0.415, 95% CI 0.056 to 0.774; p = 0.23) compared to males.CONCLUSION:
Overall, exercise regimens of studies included in this review appear to improve bone health at the hip and spine in people diagnosed with cancer. Sub-analyses suggest some influence of sex, where females had greater improvements in BMD compared to males. It is essential that future studies evaluate the dose-response of exercise training on bone health and create exercise protocols that better align with the laws of bone modelling to enhance osteogenic potential.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
/
Neoplasias
Tipo de estudo:
Guideline
/
Prognostic_studies
/
Systematic_reviews
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Osteoporos Int
Assunto da revista:
METABOLISMO
/
ORTOPEDIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália