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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
Johannes, Jeffrey W; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D; Cosulich, Sabina; Critchlow, Susan E; Degorce, Sébastien L; Di Fruscia, Paolo; Edmondson, Scott D; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J; Gunnarsson, Anders; Hande, Sudhir M; Heightman, Tom D; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J; Orme, Jonathan P; Pachl, Fiona; Packer, Martin J; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X; Zheng, Xiaolan.
Afiliação
  • Johannes JW; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Balazs A; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Barratt D; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Bista M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Chuba MD; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Cosulich S; Oncology Projects, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Critchlow SE; Bioscience, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Degorce SL; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Di Fruscia P; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Edmondson SD; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Embrey K; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Fawell S; Oncology Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Ghosh A; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Gill SJ; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Gunnarsson A; Discovery Sciences, R&D Gothenburg, AstraZeneca, KJ2, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Hande SM; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Heightman TD; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Hemsley P; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Illuzzi G; Bioscience, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Lane J; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Larner C; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Leo E; Bioscience, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Liu L; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Madin A; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Martin S; DMPK, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • McWilliams L; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • O'Connor MJ; Bioscience, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Orme JP; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Pachl F; Discovery Sciences, R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Packer MJ; Computational Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Pei X; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Pike A; DMPK, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Schimpl M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • She H; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Staniszewska AD; Bioscience, Oncology R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Talbot V; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Underwood E; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 OWG, U.K.
  • Varnes JG; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Xue L; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Yao T; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Zhang K; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Zhang AX; Discovery Sciences, R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Zheng X; Chemistry, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
J Med Chem ; 64(19): 14498-14512, 2021 10 14.
Article em En | MEDLINE | ID: mdl-34570508
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Poli(ADP-Ribose) Polimerases / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Poli(ADP-Ribose) Polimerases / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos