Development and validation of the Exercise-Induced Laryngeal Obstruction Dyspnea Index (EILODI).
J Allergy Clin Immunol
; 149(4): 1437-1444, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-34619181
ABSTRACT
BACKGROUND:
Exercise-induced laryngeal obstruction (EILO) causes exertional dyspnea and is important for its effect on quality of life, diagnostic confusion with exercise-induced asthma, and health care resource utilization. There is no validated patient-reported outcome measure specific to EILO.OBJECTIVE:
We sought to develop, validate, and define a minimal clinically important difference for a patient-reported outcome measure to be used with adolescents and young adults with EILO.METHODS:
A multidisciplinary group created a preliminary measure, modified by a 10-member participant focus group, with 20 items scored along a 5-point Likert scale. A subsequent cohort of participants recruited from a clinic, aged 12 to 21 years, with confirmed EILO by continuous laryngoscopy during exercise testing (1) completed the measure at 3 points in time over 28 days and (2) provided anchoring data in the form of a daily exercise log and categorical self-assessments of clinical improvement. Thirty additional participants without exertional dyspnea served as controls.RESULTS:
Two hundred nineteen subjects with mild to severe EILO participated in the exploratory factor analysis, which identified 7 factors within the preliminary outcome measure. After a process of item reduction, a 12-item metric with a total score ranging from 0 to 48 was developed. Mean scores of patients with EILO and healthy controls at baseline were 28.8 ± 7.4 and 4.5 ± 7.4, respectively. A minimal clinically important difference of 6 was determined by comparison of index change with changes in categorical self-assessments of improvement.CONCLUSIONS:
This is the first patient-reported outcome measure specifically designed for adolescents and young adults with EILO.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma Induzida por Exercício
/
Doenças da Laringe
/
Obstrução das Vias Respiratórias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
/
Qualitative_research
Limite:
Adolescent
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Adult
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Humans
Idioma:
En
Revista:
J Allergy Clin Immunol
Ano de publicação:
2022
Tipo de documento:
Article