Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.
J Am Heart Assoc
; 10(21): e022055, 2021 11 02.
Article
em En
| MEDLINE
| ID: mdl-34666498
ABSTRACT
Background Space travel-associated stressors such as microgravity or radiation exposure have been reported in astronauts after short- and long-duration missions aboard the International Space Station. Despite risk mitigation strategies, adverse health effects remain a concern. Thus, there is a need to develop new diagnostic tools to facilitate early detection of physiological stress. Methods and Results We measured the levels of circulating cell-free mitochondrial DNA in blood plasma of 14 astronauts 10 days before launch, the day of landing, and 3 days after return. Our results revealed a significant increase of cell-free mitochondrial DNA in the plasma on the day of landing and 3 days after return with vast ~2 to 355-fold interastronaut variability. In addition, gene expression analysis of peripheral blood mononuclear cells revealed a significant increase in markers of inflammation, oxidative stress, and DNA damage. Conclusions Our study suggests that cell-free mitochondrial DNA abundance might be a biomarker of stress or immune response related to microgravity, radiation, and other environmental factors during space flight.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Voo Espacial
/
DNA Mitocondrial
/
Astronautas
/
Ácidos Nucleicos Livres
Tipo de estudo:
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
J Am Heart Assoc
Ano de publicação:
2021
Tipo de documento:
Article