Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.

Imaide, Satomi; Riching, Kristin M; Makukhin, Nikolai; Vetma, Vesna; Whitworth, Claire; Hughes, Scott J; Trainor, Nicole; Mahan, Sarah D; Murphy, Nancy; Cowan, Angus D; Chan, Kwok-Ho; Craigon, Conner; Testa, Andrea; Maniaci, Chiara; Urh, Marjeta; Daniels, Danette L; Ciulli, Alessio

Imaide, Satomi; Riching, Kristin M; Makukhin, Nikolai; Vetma, Vesna; Whitworth, Claire; Hughes, Scott J; Trainor, Nicole; Mahan, Sarah D; Murphy, Nancy; Cowan, Angus D; Chan, Kwok-Ho; Craigon, Conner; Testa, Andrea; Maniaci, Chiara; Urh, Marjeta; Daniels, Danette L; Ciulli, Alessio.

Afiliação

Imaide S; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Riching KM; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Makukhin N; Promega Corporation, Madison, WI, USA.
Vetma V; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Whitworth C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Hughes SJ; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Trainor N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Mahan SD; Amphista Therapeutics Ltd., Newhouse, UK.
Murphy N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Cowan AD; Promega Corporation, Madison, WI, USA.
Chan KH; Promega Corporation, Madison, WI, USA.
Craigon C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Testa A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Maniaci C; GlaxoSmithKline R&D, Stevenage, UK.
Urh M; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Daniels DL; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.
Ciulli A; Amphista Therapeutics Ltd., Newhouse, UK.

Nat Chem Biol ; 17(11): 1157-1167, 2021 11.

Article em En | MEDLINE | ID: mdl-34675414

Assuntos

Ubiquitina-Proteína Ligases/metabolismo; Humanos; Proteólise

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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