Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to &#945;-Synuclein.

Teng, Xiangyu; Sheveleva, Alena; Tuna, Floriana; Willison, Keith R; Ying, Liming

Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein.

Teng, Xiangyu; Sheveleva, Alena; Tuna, Floriana; Willison, Keith R; Ying, Liming.

Afiliação

Teng X; Department of Chemistry, Imperial College London, White City Campus, London, W12 0BZ, UK.
Sheveleva A; Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Tuna F; Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Willison KR; Department of Chemistry, Imperial College London, White City Campus, London, W12 0BZ, UK.
Ying L; National Heart and Lung Institute, Imperial College London, White City Campus, London, W12 0BZ, UK.

Chemphyschem ; 22(23): 2380, 2021 12 03.

Article em En | MEDLINE | ID: mdl-34779565

ABSTRACT

ABSTRACT

The front cover artwork is provided by the group of Liming Ying at Imperial College London. The image shows that N-terminal acetylation of α-synuclein shifts the binding from the N-terminus to His50 and significantly slows down the binding reaction. Read the full text of the Article at 10.1002/cphc.202100651.

Assuntos

Cobre/metabolismo; alfa-Sinucleína/metabolismo; Acetilação; Sítios de Ligação; Cobre/química; Humanos; Cinética; Mutação; alfa-Sinucleína/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cobre / Alfa-Sinucleína Limite: Humans Idioma: En Revista: Chemphyschem Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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