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New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity.
Tang, Ben-Qin; Li, Zi-Wei; Li, Lin; Li, Bao-Jing; Bian, Ya-Qi; Yu, Guo-Dong; Chang, Yu; Lee, Simon Ming-Yuen; Zhang, Xiao-Qi.
Afiliação
  • Tang BQ; Department of Medical Science, Shunde Polytechnic, Foshan 528333, China. Electronic address: tangbenqincy@gmail.com.
  • Li ZW; NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou 510632, China.
  • Li L; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
  • Li BJ; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
  • Bian YQ; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
  • Yu GD; Department of Medical Science, Shunde Polytechnic, Foshan 528333, China.
  • Chang Y; NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou 510632, China.
  • Lee SM; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
  • Zhang XQ; NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou 510632, China. Electronic address: xqzhang74@hotmail.com.
Fitoterapia ; 156: 105085, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34793883
ABSTRACT
Four new iboga-type alkaloids, ervaoffines H-K (1-4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1-4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tabernaemontana / Alcaloides / Anti-Inflamatórios Idioma: En Revista: Fitoterapia Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tabernaemontana / Alcaloides / Anti-Inflamatórios Idioma: En Revista: Fitoterapia Ano de publicação: 2022 Tipo de documento: Article