PEG-PEI/siROCK2 inhibits Aß42-induced microglial inflammation via NLRP3/caspase 1 pathway.

Liu, Yunyun; Zhang, Han; Peng, Anping; Cai, Xiaodong; Wang, YuZhou; Tang, Ke; Wu, Xiuqin; Liang, Yanran; Wang, Limin; Li, Zhong

Liu, Yunyun; Zhang, Han; Peng, Anping; Cai, Xiaodong; Wang, YuZhou; Tang, Ke; Wu, Xiuqin; Liang, Yanran; Wang, Limin; Li, Zhong.

Afiliação

Liu Y; Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University.
Zhang H; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University.
Peng A; Department of South Campus Clinic, Sun Yat-sen Memorial Hospital, Sun Yat-sen University.
Cai X; Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University.
Wang Y; Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University.
Tang K; Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University.
Wu X; Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University.
Liang Y; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University.
Wang L; Department of Neurology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, Guangdong, China.
Li Z; Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University.

Neuroreport ; 33(1): 26-32, 2022 01 05.

Article em En | MEDLINE | ID: mdl-34874326

Assuntos

Terapia Genética/métodos; Microglia/efeitos dos fármacos; Polietilenoglicóis/farmacologia; Polietilenoimina/análogos & derivados; RNA Interferente Pequeno/administração & dosagem; Quinases Associadas a rho/antagonistas & inibidores; Peptídeos beta-Amiloides; Animais; Caspase 1/metabolismo; Células Cultivadas; Portadores de Fármacos/farmacologia; Inflamação; Camundongos; Camundongos Endogâmicos C57BL; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fragmentos de Peptídeos; Polietilenoimina/farmacologia; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polietilenoimina / Terapia Genética / Microglia / RNA Interferente Pequeno / Quinases Associadas a rho Limite: Animals Idioma: En Revista: Neuroreport Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article

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