Nano-sized zeolite-like metal-organic frameworks induced hematological effects on red blood cell.
J Hazard Mater
; 424(Pt A): 127353, 2022 02 15.
Article
em En
| MEDLINE
| ID: mdl-34879558
ABSTRACT
Understanding the toxicity of metal-organic frameworks (MOFs) is important for improving their biocompatibility in further applications, especially the hematotoxicity of MOFs due to the unavoidable contact of MOFs with blood in biomedical science. Here we report the hematotoxicity and underlying mechanisms of nano-sized zeolite-like MOFs ZIF-8 and ZIF-67 because of their wide applications in biomedical science. ZIF-67 induced significant hemolysis of red blood cell (Rb) through breaking the structure of membrane due to the generation of free radicals, whereas ZIF-8 was hematocompatible. ZIF-67 was thus internalized by Rb and then bound with hemoglobin via hydrogen bond and van der Waals force, which influenced the structure and function of hemoglobin in accompany with heme release. These findings reveal the detailed mechanism of the hematological effects of MOFs on Rb and are helpful to the assessment of the toxicity and potential health risks of MOFs and the design of biosafe MOFs for biomedical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zeolitas
/
Estruturas Metalorgânicas
Idioma:
En
Revista:
J Hazard Mater
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China