RNA circles with minimized immunogenicity as potent PKR inhibitors.

Liu, Chu-Xiao; Guo, Si-Kun; Nan, Fang; Xu, Yi-Feng; Yang, Li; Chen, Ling-Ling

Liu, Chu-Xiao; Guo, Si-Kun; Nan, Fang; Xu, Yi-Feng; Yang, Li; Chen, Ling-Ling.

Afiliação

Liu CX; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 2000
Guo SK; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 2000
Nan F; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
Xu YF; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 2000
Yang L; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech
Chen LL; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 2000

Mol Cell ; 82(2): 420-434.e6, 2022 01 20.

Article em En | MEDLINE | ID: mdl-34951963

Assuntos

Inibidores de Proteínas Quinases/farmacologia; RNA Circular/farmacologia; eIF-2 Quinase/antagonistas & inibidores; Células A549; Bacteriófago T4/enzimologia; Bacteriófago T4/genética; Células HEK293; Células HeLa; Humanos; Imunidade Inata/efeitos dos fármacos; Íntrons; Conformação de Ácido Nucleico; Inibidores de Proteínas Quinases/imunologia; RNA Ligase (ATP)/genética; RNA Ligase (ATP)/metabolismo; Precursores de RNA/genética; Precursores de RNA/metabolismo; RNA Circular/genética; RNA Circular/imunologia; Timidilato Sintase/genética; Timidilato Sintase/metabolismo; Proteínas Virais/genética; Proteínas Virais/metabolismo; eIF-2 Quinase/metabolismo

Palavras-chave

PKR; PKR inhibitor; T4 RNA ligase; circular RNA; circular RNA structure; dsRNA; group I intron; immune response; permuted Anabaena pre-tRNA group I intron; phage T4 thymidylate synthase gene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: EIF-2 Quinase / Inibidores de Proteínas Quinases / RNA Circular Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article

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