Leukotriene C4 synthase is a novel PPARÎ³ target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes.

Fujimori, Ko; Uno, Saki; Kuroda, Kyohei; Matsumoto, Chihiro; Maehara, Toko

Leukotriene C₄ synthase is a novel PPARÎ³ target gene, and leukotriene C₄ and D₄ activate adipogenesis through cysteinyl LT1 receptors in adipocytes.

Fujimori, Ko; Uno, Saki; Kuroda, Kyohei; Matsumoto, Chihiro; Maehara, Toko.

Afiliação

Fujimori K; Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address: ko.fujimori@ompu.ac.jp.
Uno S; Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Kuroda K; Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Matsumoto C; Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Maehara T; Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Biochim Biophys Acta Mol Cell Res ; 1869(3): 119203, 2022 03.

Article em En | MEDLINE | ID: mdl-34968576

Assuntos

Adipócitos/citologia; Adipogenia; Glutationa Transferase/genética; Leucotrieno C4/farmacologia; Leucotrieno D4/farmacologia; PPAR gama/metabolismo; Receptores de Leucotrienos/metabolismo; Células 3T3-L1; Adipócitos/efeitos dos fármacos; Adipócitos/metabolismo; Animais; Regulação da Expressão Gênica; Glutationa Transferase/metabolismo; Camundongos; PPAR gama/genética; Regiões Promotoras Genéticas; Receptores de Leucotrienos/genética

Palavras-chave

Adipocytes; CysLT1 receptor; CysLTs; LTC4S; PPARÎ³

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Leucotrienos / Leucotrieno D4 / Leucotrieno C4 / Adipócitos / PPAR gama / Adipogenia / Glutationa Transferase Limite: Animals Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Ano de publicação: 2022 Tipo de documento: Article

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