Modulation by 17,20S(OH)<sub>2</sub>pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis.

Brown Lobbins, Monica L; Slominski, Andrzej T; Hasty, Karen A; Zhang, Sicheng; Miller, Duane D; Li, Wei; Kim, Tae-Kang; Janjetovic, Zorica; Tuckey, Robert C; Scott, Imara-Safi O; Myers, Linda K; Postlethwaite, Arnold E

Modulation by 17,20S(OH)₂pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis.

Brown Lobbins, Monica L; Slominski, Andrzej T; Hasty, Karen A; Zhang, Sicheng; Miller, Duane D; Li, Wei; Kim, Tae-Kang; Janjetovic, Zorica; Tuckey, Robert C; Scott, Imara-Safi O; Myers, Linda K; Postlethwaite, Arnold E.

Afiliação

Brown Lobbins ML; Department of Pediatrics, University of Tennessee Health Science Center, 50 N. Dunlap, Rm. 461R, Memphis, TN 38103, USA.
Slominski AT; Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, TN 38163, USA.
Hasty KA; Department of Dermatology, University of Alabama at Birmingham, 500 22nd Street South, Birmingham, AL 35294, USA.
Zhang S; Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 6th Avenue, Birmingham, AL 35294, USA.
Miller DD; Birmingham Veterans Affairs Medical Center, 700 19th Street South, Birmingham, AL 35233, USA.
Li W; Memphis Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA.
Kim TK; Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, 1211 Union Avenue, Suite 520, Memphis, TN 38104, USA.
Janjetovic Z; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38103, USA.
Tuckey RC; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38103, USA.
Scott IO; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38103, USA.
Myers LK; Department of Dermatology, University of Alabama at Birmingham, 500 22nd Street South, Birmingham, AL 35294, USA.
Postlethwaite AE; Department of Dermatology, University of Alabama at Birmingham, 500 22nd Street South, Birmingham, AL 35294, USA.

Int J Mol Sci ; 23(1)2021 Dec 29.

Article em En | MEDLINE | ID: mdl-35008794

Assuntos

Derme/patologia; Ergocalciferóis/farmacologia; Fibroblastos/patologia; Escleroderma Sistêmico/patologia; Doadores de Tecidos; Proteína Morfogenética Óssea 7/metabolismo; Linhagem Celular; Cadeia alfa 1 do Colágeno Tipo I/metabolismo; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fibrose; Humanos; Metaloproteinase 1 da Matriz; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Inibidor 1 de Ativador de Plasminogênio/genética; Inibidor 1 de Ativador de Plasminogênio/metabolismo; Prostaglandina-E Sintases; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Inibidor Tecidual de Metaloproteinase-1/metabolismo; Proteína Gli2 com Dedos de Zinco/genética; Proteína Gli2 com Dedos de Zinco/metabolismo

Palavras-chave

TGF-ß1; collagen; fibrosis; scleroderma; vitamin D

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Doadores de Tecidos / Ergocalciferóis / Derme / Fibroblastos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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