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Anti-leukemic effect and molecular mechanism of 11-methoxytabersonine from Melodinus cochinchinensis via network pharmacology, ROS-mediated mitochondrial dysfunction and PI3K/Akt signaling pathway.
Wang, Yong-Peng; Pan, Fei; Wang, Yu-Dan; Khan, Afsar; Liu, Ya-Ping; Yang, Mei-Lian; Cao, Jian-Xin; Zhao, Tian-Rui; Cheng, Gui-Guang.
Afiliação
  • Wang YP; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
  • Pan F; Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.
  • Wang YD; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, China.
  • Khan A; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
  • Liu YP; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
  • Yang ML; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
  • Cao JX; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
  • Zhao TR; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: food363@163.com.
  • Cheng GG; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: ggcheng@kust.edu.cn.
Bioorg Chem ; 120: 105607, 2022 03.
Article em En | MEDLINE | ID: mdl-35033818
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-akt / Leucemia-Linfoma Linfoblástico de Células T Precursoras Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-akt / Leucemia-Linfoma Linfoblástico de Células T Precursoras Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China