Exogenous growth hormone functionally alleviates glucocorticoid-induced longitudinal bone growth retardation in male rats by activating the Ihh/PTHrP signaling pathway.

Peng, Guoxuan; Sun, Hong; Jiang, Hua; Wang, Qiang; Gan, Lebin; Tian, Ya; Sun, Jianhui; Wen, Dalin; Deng, Jin

Peng, Guoxuan; Sun, Hong; Jiang, Hua; Wang, Qiang; Gan, Lebin; Tian, Ya; Sun, Jianhui; Wen, Dalin; Deng, Jin.

Afiliação

Peng G; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China; Department of Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang
Sun H; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China; Department of Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: sunhong002@126.com.
Jiang H; Department of Pediatric Orthopaedic, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: 562836619@qq.com.
Wang Q; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: 1256060191@qq.com.
Gan L; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: a1181921502@126.com.
Tian Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China. Electronic address: 475323773@qq.com.
Sun J; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: 2363512492@qq.com.
Wen D; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: 13452607810@163.com.
Deng J; Department of Emergency Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, China. Electronic address: gydengjin@yeah.net.

Mol Cell Endocrinol ; 545: 111571, 2022 04 05.

Article em En | MEDLINE | ID: mdl-35063477

Assuntos

Glucocorticoides; Proteína Relacionada ao Hormônio Paratireóideo; Animais; Diferenciação Celular; Criança; Condrócitos/metabolismo; Glucocorticoides/efeitos adversos; Glucocorticoides/metabolismo; Transtornos do Crescimento/metabolismo; Hormônio do Crescimento/metabolismo; Hormônio do Crescimento/farmacologia; Lâmina de Crescimento/metabolismo; Proteínas Hedgehog/metabolismo; Humanos; Masculino; Proteína Relacionada ao Hormônio Paratireóideo/metabolismo; Proteína Relacionada ao Hormônio Paratireóideo/farmacologia; Ratos; Receptor Tipo 1 de Hormônio Paratireóideo/metabolismo; Transdução de Sinais; Transativadores/metabolismo

Palavras-chave

Chondrocyte apoptosis; Glucocorticoids; Growth hormone; Growth plate retardation; Ihh/PTHrP signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Relacionada ao Hormônio Paratireóideo / Glucocorticoides Limite: Animals / Child / Humans / Male Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2022 Tipo de documento: Article

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