Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: A cross-sectional study.

ABSTRACT

OBJECTIVE: The main aim of the study was to illustrate the association between urinary polycyclic aromatic hydrocarbons (PAHs) and their metabolites with cardiovascular diseases (CVDs), including congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, and stroke among the US population. METHODS: The National Health and Nutritional Examination Survey (NHANES) 2003-16, nationally representative data were utilized for this study. A cross-sectional observational study was designed to assess the strength of the association between urinary PAH and CVDs. The NHANES survey used a stratified multistage probability sample strategy for obtaining representative samples. Logistic regression analysis was performed to evaluate the association between PAH and the prevalence of CVDs. RESULTS: In our study, the average ages of the three different PAHs tertiles were 42.56 ± 19.68, 42.21 ± 19.51, and 43.39 ± 17.99 years, respectively. A positive association was found between the second and third tertile of urinary PAH and increased prevalence of coronary heart disease (tertile-2 OR = 1.24, 95% CI = 1.09-1.42; tertile-3 OR = 1.97, 95% CI = 1.69-2.28), angina (tertile-2 OR = 1.3, 95% CI = 1.13-1.49; tertile-3 OR = 2.07, 95% CI = 1.76-2.42), heart attack (tertile-2 OR = 1.28, 95% CI = 1.12-1.47; tertile-3 OR = 1.71, 95% CI = 1.48-1.96) and stroke (tertile-2 OR = 1.17, 95% CI = 1.02-1.33; tertile-3 OR = 1.66, 95% CI = 1.43-1.93) in total participants, respectively, with p-values less than 0.05. CONCLUSION: In conclusion, this study found a positive association between urinary PAHs and the prevalence of various CVDs among the US population.