Protecting tissue integrity and enteric function: the case for type 2 inflammation and macrophages.

Ye, Qihua; Balestrieri, Barbara; Barrett, Nora A

Ye, Qihua; Balestrieri, Barbara; Barrett, Nora A.

Afiliação

Ye Q; Jeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Balestrieri B; Jeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Barrett NA; Jeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: nbarrett@bwh.harvard.edu.

Trends Parasitol ; 38(3): 191-192, 2022 03.

Article em En | MEDLINE | ID: mdl-35078723

ABSTRACT

ABSTRACT

Type 2 inflammation (T2I) accompanies many inflammatory diseases. In a recent issue of Cell, Ahrends et al. demonstrate that helminth-elicited T2I preserves excitatory neurons and enteric function through the expansion of Arginase-1 (Arg-1)-expressing macrophages, thereby extending our understanding of the protective functions that T2I can orchestrate in inflamed barrier tissue.

Assuntos

Inflamação; Macrófagos; Humanos

Palavras-chave

Arginase-1; alternatively activated macrophages; type 2 inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inflamação / Macrófagos Limite: Humans Idioma: En Revista: Trends Parasitol Assunto da revista: PARASITOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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