D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1.
Comput Struct Biotechnol J
; 20: 766-778, 2022.
Article
em En
| MEDLINE
| ID: mdl-35126886
ARL6IP6, ADP Ribosylation Factor Like GTPase 6 interacting protein 6; ASC, Apoptosis associated speck-like protein containing a caspase recruitment domain; BLAST, Basic Local Alignment Search Tool; CD4+, Cluster of Differentiation 4+; CD8+, Cluster of Differentiation 8+; COVID-19, Coronavirus Disease 2019; Caveolin-1; Cryo-EM, Cryo Electron Microscope; Graph theory; HMOX1, Heme Oxygenase 1; IFN, Interferon; MERS-CoV, Middle East respiratory syndrome coronavirus; MMGBSA, Molecular mechanics with generalized Born and surface area solvation; Molecular dynamics simulation; Mutation; NCBI, National Centre for Biotechnology Information; NF-<ns0:math> <mrow> <mi>κ</mi> </mrow> </math>B, Nuclear factor kappa light chain enhancer of activated B cells; NLRP3, Nucleotide-binding oligomerization domain, Leucine rich repeat and Pyrin domain containing; ORF, Open Reading Frame; ORF3a; PDB, Protein Data Bank; PISA, Protein Interfaces Surfaces and Assemblies; PROVEAN, Protein Variation Effect Analyzer; RMSD, Root Mean Square Deviation; SARS-CoV-2; SUN2, SUN domain-containing protein 2; TRIM59, Tripartite motif-containing protein 59.
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01-internacional
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MEDLINE
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En
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Comput Struct Biotechnol J
Ano de publicação:
2022
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Article
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Índia