Aerobic fitness and muscle density play a vital role in postoperative complications in colorectal cancer surgery.
J Surg Oncol
; 125(6): 1013-1023, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35147981
ABSTRACT
BACKGROUND AND OBJECTIVES:
To assess the association of preoperative aerobic fitness and body composition variables with a patient's resilience to the development and impact of postoperative complications after elective colorectal cancer (CRC) surgery.METHODS:
Preoperative aerobic fitness was assessed by steep ramp test performance. Preoperative body composition was assessed by muscle mass and density determined from preoperative computed tomography scan analysis at the L3-level. Complication development and severity was graded according to Clavien-Dindo. Complication impact was assessed by the time to recovery of physical functioning after complications. Multivariable logistic regression analyses adjusted for age, sex, comorbidities and tumour location was performed.RESULTS:
Of 238 included patients, 96 (40.3%) developed postoperative complications. Better preoperative aerobic fitness decreased the likelihood to develop complications, independent of muscle mass (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.35-0.85) or muscle density (OR 0.57, 95% CI 0.36-0.89). A prolonged time to recovery following complications was associated with lower preoperative muscle density (OR 4.14, 95% CI 1.28-13.41), independent of aerobic fitness.CONCLUSIONS:
Lower aerobic fitness increases the risk of complication development, while low muscle density seems associated with a prolonged recovery from complications. Aerobic fitness and muscle density could be valuable additives to preoperative risk assessment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Procedimentos Cirúrgicos do Sistema Digestório
/
Neoplasias Colorretais
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Surg Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Holanda