Molecular determinants for the chemical activation of the warmth-sensitive TRPV3 channel by the natural monoterpenoid carvacrol.

Niu, Canyang; Sun, Xiaoying; Hu, Fang; Tang, Xiaowen; Wang, KeWei

Niu, Canyang; Sun, Xiaoying; Hu, Fang; Tang, Xiaowen; Wang, KeWei.

Afiliação

Niu C; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China.
Sun X; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China; Institute of Innovative Drugs, Qingdao University, Qingdao, China.
Hu F; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China; Institute of Innovative Drugs, Qingdao University, Qingdao, China.
Tang X; Institute of Innovative Drugs, Qingdao University, Qingdao, China; Department of Medicinal Chemistry, Qingdao University School of Pharmacy, Qingdao, China. Electronic address: xwtang1219@qdu.edu.cn.
Wang K; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China; Institute of Innovative Drugs, Qingdao University, Qingdao, China. Electronic address: wangkw@qdu.edu.cn.

J Biol Chem ; 298(3): 101706, 2022 03.

Article em En | MEDLINE | ID: mdl-35150742

Assuntos

Cimenos; Monoterpenos; Canais de Cátion TRPV; Cimenos/farmacologia; Simulação de Acoplamento Molecular; Monoterpenos/farmacologia; Canais de Cátion TRPV/metabolismo

Palavras-chave

2-APB; TRPV3; amino acid mutation; carvacrol; molecular docking; surface structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monoterpenos / Canais de Cátion TRPV / Cimenos Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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