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Evaluation of the effects of natural isoquinoline alkaloids on low density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in hepatocytes, as new potential hypocholesterolemic agents.
Maharjan, Binita; Payne, Daniel T; Ferrarese, Irene; Giovanna Lupo, Maria; Kumar Shrestha, Lok; Hill, Jonathan P; Ariga, Katsuhiko; Rossi, Ilaria; Sharan Shrestha, Shyam; Panighel, Giovanni; Lal Swagat Shrestha, Ram; Sut, Stefania; Ferri, Nicola; Dall'Acqua, Stefano.
Afiliação
  • Maharjan B; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44613, Nepal; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan.
  • Payne DT; International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki, 305-0044, Japan.
  • Ferrarese I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy.
  • Giovanna Lupo M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy.
  • Kumar Shrestha L; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan.
  • Hill JP; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan.
  • Ariga K; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan.
  • Rossi I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy.
  • Sharan Shrestha S; Department of Botany, Tribhuvan University, Kathmandu 44613, Nepal.
  • Panighel G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy.
  • Lal Swagat Shrestha R; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44613, Nepal. Electronic address: swagatstha@gmail.com.
  • Sut S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy.
  • Ferri N; Department of Medicine, of Padova, Via Giustiniani 2, 35100 Padova, Italy.
  • Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy. Electronic address: stefano.dallacqua@unipd.it.
Bioorg Chem ; 121: 105686, 2022 04.
Article em En | MEDLINE | ID: mdl-35217376
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Berberina / Pró-Proteína Convertase 9 Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Berberina / Pró-Proteína Convertase 9 Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão