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A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants.
Wang, Yanan; Wu, Haoshuang; Zhou, Zhongyi; Maitz, Manfred F; Liu, Kunpeng; Zhang, Bo; Yang, Li; Luo, Rifang; Wang, Yunbing.
Afiliação
  • Wang Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Wu H; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Zhou Z; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Maitz MF; Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Dresden 01069, Germany.
  • Liu K; Key Laboratory for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Zhang B; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Yang L; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Luo R; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Wang Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Sci Adv ; 8(9): eabm3378, 2022 Mar 04.
Article em En | MEDLINE | ID: mdl-35245113
ABSTRACT
Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the long-term function of cardiovascular materials. Here, we proposed a self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted of thrombin-responsive nanogels with anticoagulant and anti-inflammatory components. As an anticoagulant, rivaroxaban was encapsulated in nanogels cross-linked by thrombin-cleavable peptide and released upon the trigger of environmental thrombin, blocking the further coagulation cascade. The superoxide dismutase mimetic Tempol imparted the antioxidant property. Polyphenol epigallocatechin gallate (EGCG), in addition to its anti-inflammatory function in synergy with Tempol, also acted as a weak cross-linker to stabilize the coating. The effectiveness and versatility of this coating were validated using two typical cardiovascular devices as models, biological valves and vascular stents. It was demonstrated that the coating worked as a precise strategy to resist coagulation and inflammation, escorted reendothelialization on the cardiovascular devices, and provided a new perspective for designing endothelium-like functional coatings.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China