[Modern views on the role of X gene of the hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus) in the pathogenesis of the infection it causes].
Vopr Virusol
; 67(1): 7-17, 2022 03 15.
Article
em Ru
| MEDLINE
| ID: mdl-35293184
ABSTRACT
The review presents information on the role of hepatitis B virus (Hepadnaviridae Orthohepadnavirus Hepatitis B virus) (HBV) X gene and the protein it encodes (X protein) in the pathogenesis of viral hepatitis B. The evolution of HBV from primordial to the modern version of hepadnaviruses (Hepadnaviridae), is outlined as a process that began about 407 million years ago and continues to the present. The results of scientific works of foreign researchers on the variety of the influence of X protein on the infectious process and its role in the mechanisms of carcinogenesis are summarized. The differences in the effect of the X protein on the course of the disease in patients of different ethnic groups with regard to HBV genotypes are described. The significance of determining the genetic variability of X gene as a fundamental characteristic of the virus that has significance for the assessment of risks of hepatocellular carcinoma (HCC) spread among the population of the Russian Federation is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepadnaviridae
/
Carcinoma Hepatocelular
/
Hepatite B
/
Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Ru
Revista:
Vopr Virusol
Ano de publicação:
2022
Tipo de documento:
Article