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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.
Pissarnitski, Dmitri A; Kekec, Ahmet; Yan, Lin; Zhu, Yuping; Feng, Danqing D; Huo, Pei; Madsen-Duggan, Christina; Moyes, Christopher R; Nargund, Ravi P; Kelly, Terri; Zhang, Xiaoping; Carballo-Jane, Ester; Gorski, Judith; Zafian, Peter; Qatanani, Mo; Kaarsholm, Niels; Meng, Fanyu; Jia, Xiujuan; Lee, Keun-Joong; Wang, Weixun; Xu, Sherrie; Hohn, Michael J; Iammarino, Michael J; McCoy, Mark A; Okoh, Grace A; Liang, Yingkai; Hollingsworth, Scott A; Erion, Mark D; Kelley, David E; Garbaccio, Robert M; Zhang, Amy; Mu, James; Lin, Songnian.
Afiliação
  • Pissarnitski DA; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Kekec A; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Yan L; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Zhu Y; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Feng DD; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Huo P; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Madsen-Duggan C; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Moyes CR; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Nargund RP; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Kelly T; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Zhang X; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Carballo-Jane E; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Gorski J; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Zafian P; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Qatanani M; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Kaarsholm N; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Meng F; Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Jia X; Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Lee KJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Wang W; Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Xu S; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Hohn MJ; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Iammarino MJ; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • McCoy MA; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Okoh GA; Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Liang Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Hollingsworth SA; Merck & Co., Inc., South San Francisco, California 94080, United States.
  • Erion MD; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Kelley DE; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Garbaccio RM; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Zhang A; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Mu J; Merck & Co., Inc., South San Francisco, California 94080, United States.
  • Lin S; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
J Med Chem ; 65(7): 5593-5605, 2022 04 14.
Article em En | MEDLINE | ID: mdl-35298158
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos