The association between dietary acid load and odds of non-alcoholic fatty liver disease: A case-control study.
Nutr Health
; 29(4): 637-644, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-35306902
ABSTRACT
Background:
Data on the association between dietary acid load and non-alcoholic fatty liver disease (NAFLD) are scarce and controversial.Aim:
This study aimed to assess the association between dietary acid-base loads and odds of NAFLD.Methods:
In the current study, 196 cases of NAFLD (proven by a gastroenterologist using Fibroscan) and 803 age-matched controls were enrolled from the same clinic. Dietary intakes of patients with NAFLD and controls without hepatic steatosis were evaluated using a validated food frequency questionnaire. Dietary acid load was estimated using the validated potential renal acid load (PRAL) algorithm. Multivariable logistic regression model was used to estimate the odds of NAFLD across quintiles of PRAL.Results:
The mean ± SD age of the study population (43% male) was 43.28 ± 14.02 years. The mean ± SD of PRAL was -1.90 ± 7.12 for all participants. After adjustment for all known confounders, subjects in the third quintile of PRAL (nearly with neutral PRAL) had a 54% lower odds of NAFLD compared with those in the lowest quintiles of the PRAL [(OR 0.46; 95%CI 0.24-0.89), (P = 0.021)]. However, the odds of NAFLD in the highest quintiles of PRAL was not different in comparison to the lowest quintiles (OR 0.90; 95%CI 0.41-1.57).Conclusion:
In conclusion, our results have shown a modest U shaped relationship between PRAL and NAFLD. Further studies with acid-base biomarkers are needed to confirm the role of dietary acid load in the development of NAFLD and its potential mechanisms.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nutr Health
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Irã