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Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Aguilar, Rodrigo; Spencer, Kerrie B; Kesner, Barry; Rizvi, Noreen F; Badmalia, Maulik D; Mrozowich, Tyler; Mortison, Jonathan D; Rivera, Carlos; Smith, Graham F; Burchard, Julja; Dandliker, Peter J; Patel, Trushar R; Nickbarg, Elliott B; Lee, Jeannie T.
Afiliação
  • Aguilar R; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Spencer KB; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • Kesner B; Institute of Biomedical Sciences (ICB), Faculty of Medicine and Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile.
  • Rizvi NF; Merck & Co., Boston, MA, USA.
  • Badmalia MD; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Mrozowich T; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • Mortison JD; Merck & Co., Boston, MA, USA.
  • Rivera C; Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
  • Smith GF; Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
  • Burchard J; Merck & Co., Boston, MA, USA.
  • Dandliker PJ; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Patel TR; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • Nickbarg EB; Merck & Co., Boston, MA, USA.
  • Lee JT; Merck & Co., Boston, MA, USA.
Nature ; 604(7904): 160-166, 2022 04.
Article em En | MEDLINE | ID: mdl-35355011
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos X / Inativação do Cromossomo X / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos X / Inativação do Cromossomo X / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos