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Incidence of acute otitis media in children < 16 years old in Germany during 2014-2019.
Hu, Tianyan; Podmore, Bélène; Barnett, Rosemarie; Beier, Dominik; Galetzka, Wolfgang; Qizilbash, Nawab; Haeckl, Dennis; Weaver, Jessica; Boellinger, Timo; Mihm, Sarah; Petigara, Tanaz.
Afiliação
  • Hu T; Merck & Co., Inc, Kenilworth, NJ, USA. hutianyan@gmail.com.
  • Podmore B; OXON Epidemiology, London, UK.
  • Barnett R; London School of Hygiene & Tropical Medicine, London, UK.
  • Beier D; OXON Epidemiology, London, UK.
  • Galetzka W; University of Bath, Bath, UK.
  • Qizilbash N; InGef - Institute for Applied Health Research Berlin GmbH, Berlin, Germany.
  • Haeckl D; InGef - Institute for Applied Health Research Berlin GmbH, Berlin, Germany.
  • Weaver J; OXON Epidemiology, London, UK.
  • Boellinger T; London School of Hygiene & Tropical Medicine, London, UK.
  • Mihm S; WIG2 GmbH, Leipzig, Germany.
  • Petigara T; Merck & Co., Inc, Kenilworth, NJ, USA.
BMC Pediatr ; 22(1): 204, 2022 04 13.
Article em En | MEDLINE | ID: mdl-35418046
ABSTRACT

BACKGROUND:

Acute otitis media (AOM) remains a common infection in children despite the introduction of pneumococcal conjugate vaccines. This study estimated AOM incidence rates (IRs) over time in children < 16 years old in Germany following PCV13 introduction.

METHODS:

AOM episodes were identified in the InGef healthcare claims database from 2014-2019 in children aged < 16 years. Each AOM episode was classified as either simple or recurrent. Recurrent AOM was defined as 3 or more episodes identified within a 6-month period; or 4 or more episodes within a 12-month period with at least one episode in the prior 6 months. AOM-related surgical procedures within 12 months and complications within 21 days of an AOM episode were also identified. Annual IRs were calculated as number of episodes/child-years (CY) at risk. 95% Confidence intervals (95%CI) were calculated using the Wilson method. The Mann-Kendall test was used to assess trends over time.

RESULTS:

Between 2014 and 2019, the study population comprised 916,805 children with 327,726 AOM episodes, of which 15% (49,011) of all episodes were identified as recurrent AOM and 85% (278,715) as simple AOM. There were significant declines in AOM (p = 0.003) in the study population overall and in all age groups over the study period; from 101 (95%CI 101-102)/1000 CY to 79 (95%CI 78-80)/1000 CY in the total study population, from 209 (95%CI 206-212)/1000 CY to 147 (95%CI 145-150)/1000 CY in < 2-year-olds, from 239 (95%CI 237-242) to 179 (95%CI 177-182)/1000 CY in 2-4-year-olds, and from 50 (95%CI 49-50) to 38 (95%CI 37-39)/1000 CY in 5-15-year-olds. No significant trends were identified for AOM-related surgical procedures over the study period; however, AOM-related complications overall increased (p = 0.003).

CONCLUSION:

Between 2014 and 2019, AOM incidence overall declined in children aged 0-15 years in Germany. Over the study period, the incidence of complicated AOM cases increased, however the incidence of AOM-related surgical procedures remained constant. Despite the impact of PCV13, the burden associated with AOM in Germany remains substantial.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Otite Média Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child, preschool / Humans / Infant País/Região como assunto: Europa Idioma: En Revista: BMC Pediatr Assunto da revista: PEDIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Otite Média Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child, preschool / Humans / Infant País/Região como assunto: Europa Idioma: En Revista: BMC Pediatr Assunto da revista: PEDIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos