Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription.

Chong, Shasha; Graham, Thomas G W; Dugast-Darzacq, Claire; Dailey, Gina M; Darzacq, Xavier; Tjian, Robert

Chong, Shasha; Graham, Thomas G W; Dugast-Darzacq, Claire; Dailey, Gina M; Darzacq, Xavier; Tjian, Robert.

Afiliação

Chong S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Graham TGW; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dugast-Darzacq C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA.
Dailey GM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA.
Darzacq X; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA.
Tjian R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical & Health Sciences, University of California, Berkeley, Berkeley,

Mol Cell ; 82(11): 2084-2097.e5, 2022 06 02.

Article em En | MEDLINE | ID: mdl-35483357

Assuntos

Sarcoma de Ewing; Animais; Carcinogênese/genética; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica; Humanos; Mamíferos/metabolismo; Proteínas de Fusão Oncogênica/genética; Proteínas de Fusão Oncogênica/metabolismo; Proteína Proto-Oncogênica c-fli-1/genética; Proteína Proto-Oncogênica c-fli-1/metabolismo; Sarcoma de Ewing/tratamento farmacológico; Sarcoma de Ewing/genética; Ativação Transcricional/genética

Palavras-chave

EWS::FLI1; Ewing sarcoma; intrinsically disordered regions; liquid-liquid phase separation; low-complexity domains; multivalent interactions; nucleolus; single-cell and single-molecule imaging; transcription factor; transcriptional control

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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