Catastrophic DNA replication in unscheduled tetraploid cells.

Manic, Gwenola; Galluzzi, Lorenzo; Vitale, Ilio

Manic, Gwenola; Galluzzi, Lorenzo; Vitale, Ilio.

Afiliação

Manic G; Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy. Electronic address: gwenola.manic@gmail.com.
Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
Vitale I; Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy. Electronic address: iliovit@gmail.com.

Trends Genet ; 38(8): 787-788, 2022 08.

Article em En | MEDLINE | ID: mdl-35490031

ABSTRACT

ABSTRACT

Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

Assuntos

Replicação do DNA; Tetraploidia; Aneuploidia; Proteínas de Ciclo Celular/genética; Replicação do DNA/genética; Humanos; Mitose; Fase S

Palavras-chave

cell cycle checkpoint; chromosomal instability; mitotic spindle; regulated cell death; replication stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação do DNA / Tetraploidia Limite: Humans Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2022 Tipo de documento: Article

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