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Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
Peng, Shuxia; Woodruff, Jeff; Pathak, Prabhat Kumar; Matts, Robert L; Deng, Junpeng.
Afiliação
  • Peng S; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.
  • Woodruff J; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.
  • Pathak PK; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.
  • Matts RL; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.
  • Deng J; Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 Noble Research Center, Stillwater, OK 74078, USA.
Acta Crystallogr D Struct Biol ; 78(Pt 5): 571-585, 2022 May 01.
Article em En | MEDLINE | ID: mdl-35503206
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP90 / Antineoplásicos Limite: Humans Idioma: En Revista: Acta Crystallogr D Struct Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP90 / Antineoplásicos Limite: Humans Idioma: En Revista: Acta Crystallogr D Struct Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos