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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine.
Goel, Rishi R; Painter, Mark M; Lundgreen, Kendall A; Apostolidis, Sokratis A; Baxter, Amy E; Giles, Josephine R; Mathew, Divij; Pattekar, Ajinkya; Reynaldi, Arnold; Khoury, David S; Gouma, Sigrid; Hicks, Philip; Dysinger, Sarah; Hicks, Amanda; Sharma, Harsh; Herring, Sarah; Korte, Scott; Kc, Wumesh; Oldridge, Derek A; Erickson, Rachel I; Weirick, Madison E; McAllister, Christopher M; Awofolaju, Moses; Tanenbaum, Nicole; Dougherty, Jeanette; Long, Sherea; D'Andrea, Kurt; Hamilton, Jacob T; McLaughlin, Maura; Williams, Justine C; Adamski, Sharon; Kuthuru, Oliva; Drapeau, Elizabeth M; Davenport, Miles P; Hensley, Scott E; Bates, Paul; Greenplate, Allison R; Wherry, E John.
Afiliação
  • Goel RR; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Painter MM; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman
  • Lundgreen KA; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Apostolidis SA; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Rheumatology, Perelman School of Medicine at the University of
  • Baxter AE; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Giles JR; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Ca
  • Mathew D; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Pattekar A; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Reynaldi A; Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Khoury DS; Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Gouma S; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hicks P; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Dysinger S; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hicks A; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Sharma H; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Herring S; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Korte S; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kc W; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Oldridge DA; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Erickson RI; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weirick ME; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • McAllister CM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Awofolaju M; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Tanenbaum N; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Dougherty J; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Long S; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • D'Andrea K; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hamilton JT; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • McLaughlin M; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Williams JC; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Adamski S; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kuthuru O; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Drapeau EM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Davenport MP; Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Hensley SE; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bates P; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Greenplate AR; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wherry EJ; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman
Cell ; 185(11): 1875-1887.e8, 2022 05 26.
Article em En | MEDLINE | ID: mdl-35523182
ABSTRACT
We examined antibody and memory B cell responses longitudinally for ∼9-10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination. Spike- and RBD-specific memory B cells remained durable over time, and 40%-50% of RBD-specific memory B cells simultaneously bound the Alpha, Beta, Delta, and Omicron variants. Omicron-binding memory B cells were efficiently reactivated by a 3rd dose of wild-type vaccine and correlated with the corresponding increase in neutralizing antibody titers. In contrast, pre-3rd dose antibody titers inversely correlated with the fold-change of antibody boosting, suggesting that high levels of circulating antibodies may limit the added protection afforded by repeat short interval boosting. These data provide insight into the quantity and quality of mRNA-vaccine-induced immunity over time through 3 or more antigen exposures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos