Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.
Age Ageing
; 51(5)2022 05 01.
Article
em En
| MEDLINE
| ID: mdl-35639798
ABSTRACT
BACKGROUND:
mixed evidence exists on the association between muscle strength and mortality in older adults, in particular for cancer mortality.AIM:
to examine the dose-response association of objectively handgrip strength with all-cause and cancer mortality. STUDY DESIGN ANDSETTING:
data from consecutive waves from the Survey of Health, Ageing and Retirement in Europe comprising 27 European countries and Israel were retrieved. Overall, 54,807 men (45.2%; 128,753 observations) and 66,576 women (54.8%; 159,591 observations) aged 64.0 (SD 9.6) and 63.9 (SD 10.2) years, respectively, were included. Cox regression and Fine-Grey sub-distribution method were conducted.RESULTS:
during the follow-up period (896,836 person-year), the fully adjusted model showed the lowest significant risk estimates for the highest third of handgrip strength when compared with the first third (reference) in men (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.34-0.50) and women (HR, 0.38; 95% CI, 0.30-0.49) for all-cause mortality. We identified a maximal threshold for reducing the risk of all-cause mortality for men (42 kg) and women (25 kg), as well as a linear dose-response association in participants aged 65 or over. No robust association for cancer mortality was observed.CONCLUSION:
these results indicate an inverse dose-response association between incremental levels of handgrip and all-cause mortality in older adults up to 42 kg for men and 25 kg for women, and a full linear association for participants aged 65 years or over. These findings warrant preventive strategies for older adults with low levels of handgrip strength.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Força da Mão
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Age Ageing
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Espanha