Pulmonary embolism and deep vein thrombosis-comorbidities and temporary provoking factors in a register-based study of 1.48 million people.
Res Pract Thromb Haemost
; 6(4): e12714, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35677029
ABSTRACT
Background:
Knowledge on differences in patients who present with deep vein thrombosis (DVT) and those with pulmonary embolism (PE) is incomplete.Objective:
To determine comorbidities and temporary provoking factors in patients with a first-time PE or DVT.Methods:
This was a nationwide Swedish registry-based, retrospective, case-control study including 298 172 patients with first-time venous thromboembolism (VTE) and 1 185 079 controls matched for age, sex, and county of residence, free of VTE at the time of matching.Results:
Patients with PE were older than those with DVT (mean age, 69 vs 66 years) and included slightly more women (PE, 53.4% vs DVT, 52.1%). After multivariable adjustment for comorbidities (within 7 years) and temporary provoking factors (within 3 months), heart failure (PE adjusted odds ratio [aOR], 2.64 [99% confidence interval [CI], 2.55-2.73]; DVT aOR, 1.66 [99% CI, 1.60-1.72]), ischemic heart disease (PE aOR, 1.51 [99% CI, 1.47-1.56]; DVT aOR, 1.01 [99% CI, 0.98-1.04]), and chronic obstructive pulmonary disease (PE aOR, 2.51 [99% CI, 2.40-2.63]; DVT, 1.54 [99% CI, 1.47-1.62]) were among diseases that showed higher odds ratios in patients with PE than in those with DVT, compared with controls. Comorbidities registered within 6 months were associated with higher aORs than those within 7 years. The highest population attributable risks for PE were for cancer (13.0%) and heart failure (11.7%).Conclusion:
Cardiopulmonary diseases, particularly with recent onset, imply a higher risk for PE, whereas orthopedic surgery and lower-extremity fractures carry a higher risk of DVT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Res Pract Thromb Haemost
Ano de publicação:
2022
Tipo de documento:
Article