Actinoidin A2, a novel glycopeptide: production, preparative HPLC separation and characterization.
J Antibiot (Tokyo)
; 40(2): 165-72, 1987 Feb.
Article
em En
| MEDLINE
| ID: mdl-3570965
ABSTRACT
An unidentified Nocardia sp. (SK&F-AAJ-193) was isolated and found to produce actinoidin A and a novel analog which we have named actinoidin A2. This new glycopeptide antibiotic differs from actinoidin A by the presence of rhamnose instead of acosamine. This analog was isolated using Dianion HP-20 resin followed by a specific glycopeptide affinity column (Affigel-10-D-Ala-D-Ala). The purification was accomplished using preparative ion-pairing chromatography. Actinoidin A2 is active against Staphylococcus aureus and coagulase-negative Staphylococci although it is less potent than actinoidin A.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Nocardia
Limite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1987
Tipo de documento:
Article