Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells.

Shan, Kai; Feng, Ninghan; Zhu, Doudou; Qu, Hongyan; Fu, Guoling; Li, Jiaqi; Cui, Jing; Chen, Heyan; Wang, Rong; Qi, Yumin; Chen, Yong Q

Shan, Kai; Feng, Ninghan; Zhu, Doudou; Qu, Hongyan; Fu, Guoling; Li, Jiaqi; Cui, Jing; Chen, Heyan; Wang, Rong; Qi, Yumin; Chen, Yong Q.

Afiliação

Shan K; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Feng N; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Zhu D; Department of Urology, Wuxi No. 2 People's Hospital, Wuxi, 214000, Jiangsu Province, China.
Qu H; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Fu G; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Li J; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Cui J; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Chen H; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Wang R; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Qi Y; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.
Chen YQ; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.

Eur J Nutr ; 61(8): 4059-4075, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35804267

Assuntos

Ácidos Docosa-Hexaenoicos; Neoplasias; Masculino; Humanos; Ácidos Docosa-Hexaenoicos/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Peróxidos Lipídicos; Lipoxigenase/metabolismo; Lipoxigenase/farmacologia; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Lisofosfatidilcolinas/farmacologia; Linhagem Celular Tumoral; Morte Celular; Peroxidação de Lipídeos; Lipoxigenases/metabolismo; Araquidonato Lipoxigenases/metabolismo; Araquidonato Lipoxigenases/farmacologia; Aciltransferases/metabolismo; Aciltransferases/farmacologia; Carbono; Coenzima A/metabolismo; Coenzima A/farmacologia

Palavras-chave

DHA; Ferroptosis; Lipid peroxide; Lipoxygenase; ROS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Docosa-Hexaenoicos / Neoplasias Limite: Humans / Male Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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