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An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker, Ysobel R; Thorpe, Cameron; Chen, Jinfeng; Poller, Laura M; Cox, Lina; Kumar, Pawan; Lim, Wooi F; Lie, Lillian; McClorey, Graham; Epple, Sven; Singleton, Daniel; McDonough, Michael A; Hardwick, Jack S; Christensen, Kirsten E; Wood, Matthew J A; Hall, James P; El-Sagheer, Afaf H; Brown, Tom.
Afiliação
  • Baker YR; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Thorpe C; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Chen J; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Poller LM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Cox L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Kumar P; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Lim WF; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.
  • Lie L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • McClorey G; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.
  • Epple S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Singleton D; ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
  • McDonough MA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Hardwick JS; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Christensen KE; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Wood MJA; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.
  • Hall JP; Department of Pharmacy, Chemistry and Pharmacy Building, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
  • El-Sagheer AH; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Brown T; Department of Science and Mathematics, Suez University, Faculty of Petroleum and Mining Engineering, Suez, 43721, Egypt.
Nat Commun ; 13(1): 4036, 2022 07 12.
Article em En | MEDLINE | ID: mdl-35821218
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Oligonucleotídeos Fosforotioatos Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Oligonucleotídeos Fosforotioatos Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido