Prevalence of Rh, Kell, Kidd, Duffy, and MNS antigens in the Hispanic donor population of South Texas.
Immunohematology
; 38(2): 43-50, 2022 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-35852064
ABSTRACT
As population diversity in the United States expands, understanding antigen prevalence by ethnic group is essential. Differences in antigen prevalence among ethnicities have caused increased alloimmunization in chronically transfused patients. Recognizing these differences in patients and donors can reduce the risk of patients developing alloantibodies. Also, determining the antigen prevalence by ethnicity will improve the ability of blood centers to have compatible blood available. Thus far, there has not been significant published data on antigen prevalence of the U.S. Hispanic population. A retrospective cross-sectional study was performed to determine the prevalence of red blood cell (RBC) antigens, as determined by human erythrocyte antigen genotyping, in South Texas Hispanic blood donors. A total of 3455 donors, seen from 1 January 2015 to 31 May 2020, were included in the study. These donors met the inclusion criteria of self-selecting Hispanic ethnicity and successfully donating a RBC component. The antigen results for each included donor were entered into a data collection spreadsheet. The prevalence of each antigen was calculated. A binomial test was performed to determine if the observed results are statistically different as compared with the published prevalence of antigens in white and black populations. After statistical analysis, the p value for most antigens was statistically significant (p < 0.05). The Kidd blood group antigens were the only major antigens that did not show a significant difference. Cohen's h showed a large effect size for most antigens when compared with those of the black population and a small to medium effect size when compared with those of the white population. For most blood groups antigens, their prevalence in Hispanic donors was significantly different than that published for both white and black populations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Grupos Sanguíneos
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Immunohematology
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
HEMATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article