[Correlation between the rate of ethanol elimination and the psychophysiological characteristics of rats]. / Korreliatsiia mezhdu skorost'iu éliminatsii étanola i psikhofiziologicheskimi osobennostiami krys.

ABSTRACT

Ethanol elimination from the blood of rats with different psychophysiological features was studied using gas chromatographic head-space analysis in the general complex of tests aimed at determination of ethanol consumption. The selection of animals with different levels of the initial alcohol motivation was performed according to modified Porsolt's method. It was shown that the initial level of predisposition to depression-like states is in a dose-dependent correlation with the high rate of ethanol elimination. This is suggested to be one of the genetic indications which promotes the formation of the initial alcohol motivation and the development of experimental alcoholism.