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Synthesis of 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of nitrile imines with ninhydrin-derived Morita-Baylis-Hillman carbonates.
Wang, Kai-Kai; Li, Yan-Li; Jing, Jun; Chen, Rongxiang; Zhao, Na-Na; Li, Zhi-Hui; Wang, Ming-Yue; Ji, Shuo-Ke.
Afiliação
  • Wang KK; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Li YL; Medical College, Xinxiang University, Xinxiang 453000, P.R. of China.
  • Jing J; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Chen R; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Zhao NN; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Li ZH; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Wang MY; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
  • Ji SK; School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China. chenhlmei@163.com.
Org Biomol Chem ; 20(34): 6923-6930, 2022 08 31.
Article em En | MEDLINE | ID: mdl-35979893
ABSTRACT
An effective synthetic method for 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition reaction has been developed. This reaction could smoothly proceed between ninhydrin-derived Morita-Baylis-Hillman carbonates and nitrilimines to provide a wide scope of differently substituted pyrazoles in high yields (up to 95%). In addition, the reaction mechanism was also proposed to explain its regioselectivity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iminas / Ninidrina Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iminas / Ninidrina Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article