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Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman, Hannah C; Merlini, Elisa; Guijas, Carlos; DeMeester, Kristen E; Njomen, Evert; Kozina, Ellen M; Yokoyama, Minoru; Vinogradova, Ekaterina; Reardon, Holly T; Melillo, Bruno; Schreiber, Stuart L; Loreto, Andrea; Blankman, Jacqueline L; Cravatt, Benjamin F.
Afiliação
  • Feldman HC; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Merlini E; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, United Kingdom.
  • Guijas C; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121.
  • DeMeester KE; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Njomen E; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Kozina EM; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121.
  • Yokoyama M; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Vinogradova E; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Reardon HT; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121.
  • Melillo B; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02138.
  • Loreto A; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02138.
  • Blankman JL; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.
  • Cravatt BF; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, United Kingdom.
Proc Natl Acad Sci U S A ; 119(35): e2208457119, 2022 08 30.
Article em En | MEDLINE | ID: mdl-35994671
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisteína / Proteínas do Citoesqueleto / Proteínas do Domínio Armadillo Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisteína / Proteínas do Citoesqueleto / Proteínas do Domínio Armadillo Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article