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Fusobacterium nucleatum Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis.
Wei, Shuchun; Zhang, Jixiang; Wu, Xiaohan; Chen, Meilin; Huang, Hancheng; Zeng, Suqi; Xiang, Zixuan; Li, Xiangyun; Dong, Weiguo.
Afiliação
  • Wei S; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang J; Hubei Key Laboratory of Digestive System Disease, Wuhan, China.
  • Wu X; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Chen M; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Huang H; Hubei Key Laboratory of Digestive System Disease, Wuhan, China.
  • Zeng S; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Xiang Z; Hubei Key Laboratory of Digestive System Disease, Wuhan, China.
  • Li X; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Dong W; Hubei Key Laboratory of Digestive System Disease, Wuhan, China.
Inflamm Bowel Dis ; 29(1): 9-26, 2023 01 05.
Article em En | MEDLINE | ID: mdl-35998069
Fusobacterium nucleatum­derived extracellular vesicles (Fn-EVs) alter the microRNA profile of intestinal epithelial cells and colitis tissues, especially the expression of miR-574-5p. Fn-EVs mediate experimental colitis severity through miR-574-5p/CARD3­dependent autophagy activation. Hence, inhibiting Fn-EV­activated autophagy or targeting the miR-574-5p/CARD3 axis may be potential new therapeutic strategies in ulcerative colitis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / MicroRNAs / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / MicroRNAs / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China