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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.
Jiang, Ying; Alam, John J; Gomperts, Stephen N; Maruff, Paul; Lemstra, Afina W; Germann, Ursula A; Stavrides, Philip H; Darji, Sandipkumar; Malampati, Sandeep; Peddy, James; Bleiwas, Cynthia; Pawlik, Monika; Pensalfini, Anna; Yang, Dun-Sheng; Subbanna, Shivakumar; Basavarajappa, Balapal S; Smiley, John F; Gardner, Amanda; Blackburn, Kelly; Chu, Hui-May; Prins, Niels D; Teunissen, Charlotte E; Harrison, John E; Scheltens, Philip; Nixon, Ralph A.
Afiliação
  • Jiang Y; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Alam JJ; Department of Psychiatry, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.
  • Gomperts SN; EIP Pharma Inc, 20 Park Plaza, Suite 424, Boston, MA, 02116, USA. jalam@eippharma.com.
  • Maruff P; Massachusetts Alzheimer's Disease Research Center, 114 16th Street, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
  • Lemstra AW; Cogstate Ltd, Runway East Borough Market, 20 St. Thomas St, London, SE1 9RS, UK.
  • Germann UA; Alzheimer Center Amsterdam, Amsterdam Neuroscience - Neurodegeneration, Amsterdam UMC at VUmc, De Boelelaan 1118, 1081 HZ, Amsterdam, the Netherlands.
  • Stavrides PH; Brain Research Center, Cronenburg 2, 1081 GN, Amsterdam, the Netherlands.
  • Darji S; EIP Pharma Inc, 20 Park Plaza, Suite 424, Boston, MA, 02116, USA.
  • Malampati S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Peddy J; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Bleiwas C; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Pawlik M; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Pensalfini A; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Yang DS; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Subbanna S; Department of Psychiatry, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.
  • Basavarajappa BS; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Smiley JF; Department of Psychiatry, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.
  • Gardner A; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Blackburn K; Department of Psychiatry, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.
  • Chu HM; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Prins ND; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
  • Teunissen CE; Department of Psychiatry, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.
  • Harrison JE; Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, 1051 Riverside Dr., New York, NY, 10032, USA.
  • Scheltens P; Department of Psychiatry, Columbia University, 1051 Riverside Dr., New York, NY, 10032, USA.
  • Nixon RA; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
Nat Commun ; 13(1): 5308, 2022 09 21.
Article em En | MEDLINE | ID: mdl-36130946
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Prosencéfalo Basal Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Prosencéfalo Basal Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos